The Mosque of Sultan al-Mu'ayyad is a Mosque in Cairo next to Bab Zuwayla built by the Mamluk sultan Al-Mu'ayyad Sayf ad-Din Shaykh from whom it takes its name. Construction began in 1415 and the mosque was completed in 1421. The complex included a Friday mosque and a madrasa for four madhhabs It replaced a prison which originally stood next to Bab Zuwayla.

The mosque was intended as a funerary complex and for use in Friday prayers, but its greatest purpose was that of a madrasa for Sufi students, according to al-Maqrizi's story of its origins, The Mosque of Sultan al-Mu'ayyad was the last great hypostyle mosque built in Cairo, throughout its history, the Mosque of Sultan al-Mu'ayyad has undergone extensive renovations. Even early on, reconstruction was necessary, In 2001, the mosque again underwent restorations, this time by the order of the Egyptian Ministry of Culture.